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A subset of CB002 xanthine analogs bypass p53-signaling to restore a p53 transcriptome and target an S-phase cell cycle checkpoint in tumors with mutated-p53

Mutations in TP53 occur commonly in the majority of human tumors and confer aggressive tumor phenotypes, including metastasis and therapy resistance.CB002 and structural-analogs restore p53 signaling in tumors with mutant-p53 but we find that unlike other xanthines such as caffeine, pentoxifylline, and theophylline, they do not deregulate the G2 ch

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Recommendations for how to communicate bad news

The communication, along with the control of the symptoms and the emotional support are the basic instruments that are used in the daily development of our profession.To be little capable at the time of notifying bad news can generate an added suffering unnecessary in the person who receives the new Sneakers and a deterioration in the relation prof

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